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FOR 926

DFG-Forschergruppe 926: "Pathologie und Pathophysiologie des Endocannabinoidsystems"
 
Projektsprecher
Prof. Dr. Andreas Zimmer
Life & Brain Center
Rheinische Friedrich Wilhelms-Universität Bonn
Sigmund-Freud-Straße 25, D-53127 Bonn
Tel.: 0228-6885303
E-Mail: a.zimmer@uni-bonn.de
 
Allgemeine Zusammenfassung der Aufgaben und Ziele
The goal of this multi-disciplinary Research Unit is the analysis of the endocannabinoid system (ECS) in the maintenance of homeostasis as well as studies on the consequences of chronic changes in ECS activity. These projects aim at elucidating commonalities in the function or dysfunction of the ECS in normal physiology and pathophysiology. Our research is driven by the overall hypothesis that endocannabinoid-mediated feedback mechanisms that maintain homeostasis under normal conditions contribute to pathogenic processes under chronic stress and life-challenging conditions. A better understanding of the underlying regulatory mechanism should enable us to test novel therapeutic approaches that involve the modulation of ECS activity.

Beteiligte Projekte
  • Detection and quantification of endocannabinoids by LC-MS/MS
  • Function of the endocannabinoid system in normal and pathological ageing processes of the brain
  • Function of the endocannabinoid system in normal and pathological ageing processes of the brain
  • Interaction of the endocannabinoid system with Alzheimer¿s disease: influence on amyloid precursor protein-processing gap junction communication and potential neuroprotective effects
  • Modulation of the exocytotic and carrier-mediated transmitter release by endogenous and exogenously added cannabinoids
  • The endocannabinoid system in fear memory processing
  • The role of cannabinoid CB2 receptors in bone remodeling: Functional analysis of human CB2 protein variants and generation of bone cell specific CB2 receptor knockout mice.
  • The role of cannabinoids and their receptors in the cardiovascular system: regulation of heart function and response to injury.
  • The role of endocannabionoids in human pain perception habituation of pain perception and in prevention/reversal of pain plasticity (implicit pain memory).
  • The role of the endocannabinoid system in the regulation of cellular immune responses in the skin
 
Laufzeit
seit 2008

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